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ProteomicsClonal plasma cells in AL amyloidosis are dependent on pro-survival BCL-2 family proteins and sensitive to BH3 mimetics alone and in combination with front-line therapies
Amyloid light chain amyloidosis (AL) is an incurable protein misfolding disorder characterized by the production of amyloidogenic immunoglobulin light chains by clonal populations of plasma cells. These abnormal light chains accumulate as amyloid fibrils in vital organs and cause multi-organ dysfunc...
ORGANISM(S): Homo sapiens (Human) 
2022-10-03 | PXD024119 | Pride
Al amyloidosis bcl-2 apoptosis bh3 bortezomib proteasome inhibition 
TranscriptomicsEfficacy of bortezomib in a direct xenograft model of primary effusion lymphoma
Primary effusion lymphoma is an aggressive B-cell lymphoma most commonly diagnosed in HIV-positive patients and universally associated with Kaposi’s sarcoma-associated herpesvirus (KSHV). Chemotherapy treatment of PEL yields only short-term remissions in the vast majority of patients yet efforts to ...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-22594 | biostudies-arrayexpress
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