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GenomicsmethylSig: a whole genome DNA methylation analysis pipeline
DNA methylation plays critical roles in gene regulation and cellular specification without altering DNA sequences. The wide application of reduced representation bisulfite sequencing (RRBS) and whole genome bisulfite sequencing (bis-seq) opens the door to study DNA methylation at single CpG site re...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-55569 | biostudies-arrayexpress
TranscriptomicsSubtypes of HPV-positive head and neck cancers are associated with HPV characteristics, copy number variations, PIK3CA mutation, and pathway signatures. [RNA-Seq]
Purpose: There is substantial heterogeneity within the human papillomavirus (HPV) positive head and neck cancer (HNC) tumors that predispose them to different outcomes, however this subgroup is poorly characterized due to various historical reasons. Experimental Design: we perform unsupervised gene...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-74927 | biostudies-arrayexpress
TranscriptomicsSkeletal muscle gene expression in response to resistance exercise: sex specific regulation
The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exercise. We u...
ORGANISM(S): Homo sapiens 
2010-12-06 | E-GEOD-24235 | biostudies-arrayexpress
TranscriptomicsSex and aging effect on skeletal muscle transcriptome in humans
The aim of this investigation was to develop a global view of muscle transcriptional differences between older men and women and with aging for each sex. Muscle biopsies were obtained from the biceps brachii of young (age 19~28yrs) and older (age 65~76 yrs) men (7 young, 4 older) and women (7 young,...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-38718 | biostudies-arrayexpress
TranscriptomicsDevelopmental transcriptome analysis of human erythropoiesis
We profiled the dynamic, comprehensive transcriptome during human erythroid differentiation in vitro. The erythroid cells at day 4, 8, 11 and 14 differentiation stages were harvested and sequenced by Illumia 72 bp paired-end sequencing format, respectively. Expression profiling of erythroid cells on...
ORGANISM(S): Homo sapiens 
2014-05-05 | E-GEOD-54602 | biostudies-arrayexpress
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