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TranscriptomicsTranscription profiling of hearts from DTG-positive mice before and after the induction of the transgene Akt1 at different time points to investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure
To investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure, a tetracycline-regulated transgenic system to conditionally switch a constitutively-active form of the Akt1 protein kinase on or off in the adult heart was developed. Short-term activation (2 we...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3383 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skeletal muscle-specific, conditional transgenic mouse expressing a constitutively-active form of Akt1
In contrast to the well-established role of oxidative muscle fibers in regulating fatty acid oxidation and whole body metabolism, little is known that about the function of fast/glycolytic muscle fibers in these processes. Here, we generated a skeletal muscle-specific, conditional transgenic mouse e...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9484 | biostudies-arrayexpress
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