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MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
TranscriptomicsExpression data from Evi1-transduced primary bone marrow cells
Evi1 is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders. Particularly, high Evi1 expression defines one of the largest clusters in acute myeloid leukemia and is significantly associated with extremely poor prognosis. Improvement of the t...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22434 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rice dwarf mutant Fukei71
Microarray analysis was used to identify candidate genes involved in the formation of hydroxycinnamoyl-arabinoxylan (AX) and secondary cell walls in rice. Gene expression in the internode pith parenchyma of Fukei71 (F71), the rice dwarf mutant that accumulates large amounts of hydroxycinnamoyl-AX in...
ORGANISM(S): Oryza sativa Japonica Group 
2010-04-01 | E-MEXP-2311 | biostudies-arrayexpress
UnknownNovel matrix proteins of Pteria penguin pearl oyster shell nacre homologous to the jacalin-related β-prism fold lectins.
Not available
S-EPMC4223035 | biostudies-literature
UnknownMpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.
Not available
S-EPMC1951132 | biostudies-literature
TranscriptomicsGene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and oligonucleotide microarray analysis
Background. Oral carcinogenesis is a complex process involving multiple genes. However, the genetic changes involved in this process are not demonstrated in the identical oral squamous carcinomas (OSCCs). Methods. According to the pathological characteristics, parts of normal tissues, oral dysplasti...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-35261 | biostudies-arrayexpress
UnknownAssociation of low-dose glucocorticoid use and infection occurrence in systemic lupus erythematosus patients: a prospective cohort study.
Not available
S-EPMC9330647 | biostudies-literature
UnknownCombi-CRISPR: combination of NHEJ and HDR provides efficient and precise plasmid-based knock-ins in mice and rats.
Not available
S-EPMC7864826 | biostudies-literature
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