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TranscriptomicsNon-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
A synthetic analog of sphingosine named FTY720 (Fingolimod), phosphorylated by sphingosine kinase-2, interacts with sphingosine-1-phosphate (S1P) receptors expressed on various cells. FTY720 suppresses the disease activity of multiple sclerosis (MS) chiefly by inhibiting S1P-dependent egress of auto...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28642 | biostudies-arrayexpress
TranscriptomicsGene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33500 | biostudies-arrayexpress
TranscriptomicsGene expression profile of DAP12 knockdown THP-1 cells following exposure to phorbol 12-myristate 13-acetate
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33503 | biostudies-arrayexpress
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