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TranscriptomicsZbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages
This SuperSeries is composed of the following subset Series: GSE37028: Microarray analysis of Zbtb46 KO CD4+ Splenic DCs and bone marrow erythroid progenitors GSE37029: Microarray analysis of WT bone marrow myeloid progenitors, BM cultured with GM-CSF and M-CSF, and monocytes treated with GM-CSF Ref...
ORGANISM(S): Mus musculus 
2012-05-20 | E-GEOD-37030 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Zbtb46 KO CD4+ splenic DCs and bone marrow erythroid progenitors
Zbtb46 represses G-CSFR and LifR in cDCs Zbtb46 does not significantly affect gene expression in erythroid progenitors WT, Het, and KO cells were sorted from BM or spleen and analyzed. Pre MegE cells were sorted as CD117+ CD150+ CD105-CD41-CD16/32-. Pre CFU-E cells were sorted as CD117+ CD150+ CD10...
ORGANISM(S): Mus musculus 
2012-05-20 | E-GEOD-37028 | biostudies-arrayexpress
ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-01 | MSV000088298 | MassIVE
TranscriptomicsMicroarray analysis of C. rodentium infected colons
Defense against attaching and effacing (A/E) bacteria requires the sequential generation of IL-23 and IL-22 to induce protective mucosal responses. While the critical source of IL-22 has been identified as CD4+ and Nkp46+ innate lymphoid cells (ILCs), the precise source of IL-23 is unclear. Here, we...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45682 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of WT and Notch2-deficient classical DC subsets
Defense against attaching and effacing (A/E) bacteria requires the sequential generation of IL-23 and IL-22 to induce protective mucosal responses. While the critical source of IL-22 has been identified as CD4+ and Nkp46+ innate lymphoid cells (ILCs), the precise source of IL-23 is unclear. Here, we...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45681 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of WT ESAM+ and ESAM- cDC subsets
Defense against attaching and effacing (A/E) bacteria requires the sequential generation of IL-23 and IL-22 to induce protective mucosal responses. While the critical source of IL-22 has been identified as CD4+ and Nkp46+ innate lymphoid cells (ILCs), the precise source of IL-23 is unclear. Here, we...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45679 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of WT bone marrow myeloid progenitors, BM cultured with GM-CSF and M-CSF, and monocytes treated with GM-CSF
Analysis of genes induced in DC precursors and in BM cells and monocytes treated with GM-CSF For progenitor arrays, bone marrow progenitors (CMP, GMP, CDP, and pre-cDC) were harvested from WT C57Bl/6 mice. For culture arrays, BM was cultured in the presence of GM-CSF or M-CSF and adherent and non-a...
ORGANISM(S): Mus musculus 
2012-05-20 | E-GEOD-37029 | biostudies-arrayexpress
TranscriptomicsIRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Affymetrix).
While most blood lineages are assumed to mature through a single cellular and developmental route downstream of hematopoietic stem cells (HSCs), dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downst...
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34892 | biostudies-arrayexpress
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