Sort   by:  
 Page size 
ProteomicsA chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase
Serine-threonine phosphatases have been challenging to study because of the lack of specific inhibitors. Their catalytic domains are druggable, but these are shared or very similar between individual phosphatase complexes, precluding their specific inhibition. Instead, phosphatase complexes achieve ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-06 | PXD056390 | Pride
Phosphoproteomics Phosphatase Phosphorylation Pp2a-b56 
MetabolomicsCell overgrowth potentiates osmotic and replication stresses to promote p38/p53/p21-dependent senescence
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER...
2025-10-24 | MTBLS8698 | MetaboLights
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
UnknownCDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal
Not available
S-SCDT-EMBOJ-2021-108599 | biostudies-other
UnknownA bifunctional kinase-phosphatase module balances mitotic checkpoint strength and microtubule attachment dynamics
Not available
S-SCDT-10_15252-EMBJ_2022112630 | biostudies-other
Sort   by:  
 Page size