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TranscriptomicsRNAseq of mutant TP53 HCT116 cell line clones generated via CRISPR editing
To compare the impact of several TP53 mutant variants in an isogenic setting, different TP53 mutations were introduced in HCT116 colorectal carcinoma cells. This parental cell line is wild-type for TP53 and shows a prototypical p53 response. To ensure unambigous genotype-phenotype correlations, the ...
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-12734 | biostudies-arrayexpress
TranscriptomicsAmplicon-Screening of exonic RNA in exon-wide mutant cell libraries of mutant TP53 (Exons 5, 6, 7, 8) in HCT116 cells generated via CRISPR editing
To compare the impact of TP53 mutant variants in exon-wide mutant cell libraries, comprehensive mutome libraries of TP53 affecting the Exons 5, 6, 7 and 8 were generated systematically by CRISP/Cas9 editing in HCT116 colorectal carcinoma cells.
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-12861 | biostudies-arrayexpress
GenomicsAmplicon-Screening of exonic DNA regions in exon-wide mutant cell libraries of mutant TP53 (Exons 5, 6, 7, 8) in HCT116 cells generated via CRISPR editing
To compare the impact of TP53 mutant variants in exon-wide mutant cell libraries, comprehensive mutome libraries of TP53 affecting the Exons 5, 6, 7 and 8 were generated systematically by CRISP/Cas9 editing in HCT116 colorectal carcinoma cells.
ORGANISM(S): Homo sapiens 
2024-10-16 | E-MTAB-12857 | biostudies-arrayexpress
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