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TranscriptomicsExpression in wild type and TgDREAM mouse B cells unstimulated or 2 days after LPS+IL4 stimulation
DREAM/KChIP-3 is a calcium-dependent transcriptional repressor highly expressed in immune cells. Transgenic mice expressing a dominant active DREAM mutant show reduced serum immunoglobulin levels. In vitro assays show that reduced immunoglobulin secretion is an intrinsic defect of transgenic B cells...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-16874 | biostudies-arrayexpress
TranscriptomicsBasal expression in daDREAM transgenic mouse hippocampus
Changes in nuclear Ca2+ homeostasis activate specific gene expression programs and are central to the acquisition and the plastic storage of memories. DREAM /KChIP proteins form heterotetramers that bind DNA and repress transcription in a Ca2+-dependent manner. Single ablation of one member of the D...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-17844 | biostudies-arrayexpress
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