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TranscriptomicsExposure of zebrafish embryos to organic solvents, dimethylformamide and dimethyl sulfoxide
Current aquatic chemical testing guidelines recognise that solvents can potentially interfere with the organism or environmental conditions of aquatic ecotoxicity tests and therefore recommend concentration limits for their use. These recommendations are based on evidence of adverse solvent effects ...
ORGANISM(S): Danio rerio 
2011-10-05 | E-GEOD-32593 | biostudies-arrayexpress
TranscriptomicsZebrafish embryos: exposure to 3,4-dichloraniline, 2,4-dichlorophenol, pentachlorophenol, and cadmium chloride
Large-scale toxicogenomic screening approaches offer great promise for generating a bias-free, system-wide view of toxicological effects and modes-of-action of chemicals and ecotoxicants. Early applications of microarray technology have identified relatively small groups of responding genes with whi...
ORGANISM(S): Danio rerio 
2010-05-06 | E-GEOD-21680 | biostudies-arrayexpress
TranscriptomicsWhole-transcript expression data of BRD4 inhibition in uveal melanoma
G protein alpha q and 11 are mutated in 80% of uveal melanoma. We observed that treatment with the BRD4 inhibitor JQ1 resulted in different phenotypic responses in G-protein mutant uveal melanoma cell lines and wild type uveal melanoma cell lines. We used microarrarys to profile the gene expression ...
ORGANISM(S): Homo sapiens 
2015-02-19 | E-GEOD-66048 | biostudies-arrayexpress
TranscriptomicsWhole Blood Gene Expression Profiling Predicts Therapeutic Response in Polyarticular Juvenile Idiopathic Arthritis at 4 Months
To determine whether gene expression profiles from peripheral whole blood could be used to determine therapeutic outcome in a cohort of children with newly diagnosed polyarticular JIA. 19 samples were obtained from healthy childhood controls and 93 samples from patients with juvenile idiopathic arth...
ORGANISM(S): Homo sapiens 
2014-02-26 | E-GEOD-55319 | biostudies-arrayexpress
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