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UnknownPhase I study of ARN-509, a novel antiandrogen, in the treatment of castration-resistant prostate cancer.
Not available
S-EPMC3782148 | biostudies-literature
TranscriptomicsETV1 knockdown in GIST cell lines
ETV1 is highly expressed in GIST cells and required for their survival and growth. To identify genes and pathways regulated by ETV1 in GIST, we performed expression profiles of GIST cells after ETV1 knockdown. Two GIST cell lines (GIST48 and GIST882) were infected in duplicate with three shRNA virus...
ORGANISM(S): Homo sapiens 
2010-10-13 | E-GEOD-19396 | biostudies-arrayexpress
TranscriptomicsDexamethasone treatment of VCaP prostate cells
The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. We identified glucocorticoid receptor (GR) activity as modulator of enzalutamite sensitivity in the VCaP prostate cancer cell line. The GR agonist dexamethasone was sufficient to co...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51872 | biostudies-arrayexpress
TranscriptomicsImatinib Treatment of GIST882
Gastrointestinal Stromal Tumor frequently harbor mutations in the KIT receptor tyrosine kinase and depend on its activity for growth. This underlies the efficacy of imatinib, a inhibitor of KIT activity, in GIST management. GIST882 is a patient derived GIST cell line that harbor a K640E exon 13 KIT ...
ORGANISM(S): Homo sapiens 
2010-10-13 | E-GEOD-22433 | biostudies-arrayexpress
GenomicsMapping of ETV1 genomic binding sites in gastrointestinal stromal tumor (GIST).
ETV1 is highly expressed in GIST and their presumed precursors--the interstitial cells of Cajal. ETV1 is required for survival for both GIST and ICC and regulates GIST signature genes. Here, using Illumina-Solexa based next-generation sequencing of ETV1 chromatin immunoprecipates (ChIP-Seq), we defi...
ORGANISM(S): Homo sapiens 
2010-10-14 | E-GEOD-22441 | biostudies-arrayexpress
TranscriptomicsAndrogen and Glucocorticoid stimulation of LREX' cells in vitro
The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Using the LnCaP/AR xenograft model, we identified induction of glucocorticoid receptor (GR) expression as a common feature of drug resistant tumors. From a resistant xenograft tumor...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51871 | biostudies-arrayexpress
GenomicsGlucocorticoid Receptor and Androgen Receptor DNA binding in LREX'
LREX' are a LnCAP/AR subline with natural expresison of the glucocorticoid receptor. We used the model to compare the AR and GR cistromes in prostate tissue. We determined the GR cistrone in the presence of Dex (100nM) treatment and the AR cistrome in the presene of DHT (1nM) treatment.
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51497 | biostudies-arrayexpress
TranscriptomicsLNCAP/AR and a LnCAP/AR subline (LREX') with acquired resistance to 2nd generation antiandrogens
The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Using the LnCaP/AR xenograft model, we identified induction of glucocorticoid receptor (GR) expression as a common feature of drug resistant tumors. From a resistant xenograft tumor...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51873 | biostudies-arrayexpress
TranscriptomicsPTEN intact and NULL prostates in intact and castrate mice.
We performed expression profiling of prostates of 3 month wild-type and PTEN NULL mice and assessed the response to 3 days of castration. Seven three month old WT and PbCre x PTEN f/f (PTEN NULL) mice were used. They are in the C57B6 background. Three mice in each group were castrated. Three days af...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-24691 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate
Current knowledge of prostate cancer genomes is largely based on relatively small patient cohorts using single modality analysis platforms. Here we report concordant assessment of DNA copy number, mRNA and microRNA expression and focused exon resequencing in prostate tumors from 218 patients with pr...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-21036 | biostudies-arrayexpress
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