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ProteomicsProteomics of tumor associated microglia, tumor tissue from SB28 glioblastoma mice, and control microglia
The 18 kDa translocator protein (TSPO) emerges as an important PET biomarker to assess the tumor microenvironment (TME) in glioblastoma. However, various cellular sources hamper interpretation and biological understanding of TSPO and other immune biomarkers in the TME. Thus, we established a novel m...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-30 | PXD044033 | Pride
Tumor tissue Microglia Tumor associated microglia Sb28 glioblastoma 
Unknown18 kDa translocator protein positron emission tomography facilitates early and robust tumor detection in the immunocompetent SB28 glioblastoma mouse model.
Not available
S-EPMC9621314 | biostudies-literature
UnknownResponsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
Not available
S-EPMC6279422 | biostudies-literature
TranscriptomicsLocal Delivery of an IL-15 Superagonist Using a Replicating Retrovirus Improves Survival and Lymphocyte Infiltration in Poorly Immunogenic Mouse Models of Glioblastoma
Glioblastoma (GBM) leads to severe systemic and local immunosuppression, and immunotherapies have had limited success. One of the hallmarks of GBM immunosuppression is poor T cell infiltration and significant intratumoral T cell dysfunction. IL-15 is a promising immunocytokine with the ability to st...
ORGANISM(S): Mus musculus 
2024-11-01 | GSE278988 | GEO
GenomicsHorizontal mitochondrial transfer from microenvironment increases glioblastoma tumorigenicity
Horizontal mitochondrial transfer from microenvironment increases glioblastoma tumorigenicity
PRJNA758703 | ENA
TranscriptomicsTreating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin)
drugs targeting mitosis might affect the tumor microenvironment and sensitize cancer cells to immunotherapy. BAL101553 monotherapy increased survival in immune checkpoint blockade–resistant SB28 glioblastoma tumors and synergized with anti-CD40 antibody
ORGANISM(S): Mus musculus 
2021-10-23 | GSE186302 | GEO
UnknownIL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma.
Not available
S-EPMC11952432 | biostudies-literature
UnknownRemote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome.
Not available
S-EPMC11474166 | biostudies-literature
GenomicsTREM2 inhibition triggers anti-tumor cell activity of myeloid cells in glioblastoma [RNAseq]
TREM2 inhibition triggers anti-tumor cell activity of myeloid cells in glioblastoma [RNAseq]
PRJNA939127 | ENA
GenomicsTREM2 inhibition triggers anti-tumor cell activity of myeloid cells in glioblastoma [scRNA]
TREM2 inhibition triggers anti-tumor cell activity of myeloid cells in glioblastoma [scRNA]
PRJNA939552 | ENA
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