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MetabolomicsDetermination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (Method validation)

SCFAs are the main microbial fermentation products from dietary fibers in colon and play a key role in keeping healthy in the whole-body. However, differences of SCFAs concentration in the serum and colon samples collected from rats had attracted few attentions. Here, we optimized the extract and...

2020-11-24 | MTBLS2146 | MetaboLights
MetabolomicsDetermination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (SCFA serum and colon content determination)

SCFAs are the main microbial fermentation products from dietary fibers in colon and play a key role in keeping healthy in the whole-body. However, differences of SCFAs concentration in the serum and colon samples collected from rats had attracted few attentions. Here, we optimized the extract and...

2020-11-24 | MTBLS2088 | MetaboLights
MetabolomicsA Compromised Developmental Trajectory of the Infant Gut Microbiome and Metabolome in Atopic Eczema -(targeted SCFAs profiling)
Not available
ORGANISM(S): Homo sapiens 
ST001431 | MetabolomicsWorkbench
TranscriptomicsTranscriptomic analysis for response of EHEC to short chain fatty acids
Enterohaemorrhagic Escherichia coli (EHEC) is an emerging pathogen that causes diarrhea and heamolytic uremic syndrome. Expression of genes associated to pathogenicity is strictly regulated by environmental factors. Since short chian fatty acids (SCFAs) are present in intestinal tract which is a tar...
ORGANISM(S): Escherichia coli 
2010-05-17 | E-GEOD-12903 | biostudies-arrayexpress
UnknownSCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor.
Not available
S-EPMC3115979 | biostudies-literature
TranscriptomicsThe effect of short-chain fatty acids (SCFAs) on human monocyte-derived dendritic cells (DCs)
We investigated the influence of SCFAs on human, monocyte derived DCs that represent a reliable in vitro model to study circulating DCs, one of the key regulators of our immune system. We studied the individual effect exerted by SCFA, the main metabolic end-products of fermentation by anaerobic bact...
ORGANISM(S): Homo sapiens 
2015-12-28 | GSE66989 | GEO
TranscriptomicsGut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
Acetate, propionate and butyrate are the main short-chain fatty acids (SCFAs) that arise from the fermentation of fibers by the colonic microbiota. While many studies focus on the regulatory role of SCFAs, their quantitative role as a catabolic or anabolic substrate for the host has received relativ...
ORGANISM(S): Mus musculus 
2013-10-21 | E-GEOD-45926 | biostudies-arrayexpress
OtherData for: Short-chain fatty acids activate acetyltransferase p300/CBP
The short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced in large quantities by the gut microbiome and contribute to a wide array of physiological processes. While the underlying mechanisms are largely unknown, many effects of SCFAs have been traced to changes in epigenetic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-12 | MSV000087800 | MassIVE
TranscriptomicsCutaneous SCFAs are reduced in infants with atopic dermatitis, and the SCFA-sensing receptor GPR43 modulates skin barrier integrity and inflammation
Background: Early-life skin colonization by commensal microbes is associated with reduced risk of atopic dermatitis (AD), but underlying mechanisms remain unclear. Short-chain fatty acids (SCFAs), gut microbiome-derived metabolites with immunomodulatory functions, are also produced by cutaneous comm...
ORGANISM(S): Mus musculus 
2026-08-24 | GSE336219 | GEO
UnknownUnraveling the gut microbiota-SCFAs-cathepsin C pathway in preeclampsia: a novel therapeutic target.
Not available
S-EPMC12665775 | biostudies-literature
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