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TranscriptomicsA piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
We examined the construction of the piRNA system in the restricted developmental window in which methylation patterns are set during mammalian embryogenesis. We find robust expression of two Piwi family proteins, MIWI2 and MILI. Their associated piRNA profiles reveal differences from Drosophila wher...
ORGANISM(S): Mus musculus 
2008-10-01 | E-GEOD-12757 | biostudies-arrayexpress
Genomicsena-DATASET-LUDJHU-29-01-2018-17:38:21:660-204 - samples
Sequencing data from 1,005 cancer patients and 812 healthy controls. All samples prepared using Safe-SeqS technology and sequenced on an Illumina MiSeq and/or HiSeq instrument. Paired FASTQ files for correspond to read 1 and the index read present (R and I respectively).
EGAD00001003931 | EGA
GenomicsDetection and localization of surgically resectable cancers with a multi-analyte blood test
Earlier detection is key to reducing cancer deaths. Here we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1,005 patients with clinically detected can...
EGAS00001002764 | EGA
TranscriptomicsGIST cell cycle dysregulation is required for progression to high-risk disease but not for resistance to kinase inhibitors
Background: To understand the transcriptional consequences of a TP53 modulation in the GIST cell context, we treated GIST430 with increasing doses of the MDM2-inhibitor nutlin-3 (racemate). In this study, 3’ end RNA Sequencing (3SEQ) was used to expression profile GIST430 cell lines treated with DMS...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-59841 | biostudies-arrayexpress
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