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GenomicsSynthetic antagonist of a histone reader reveals and targets genes essential for inflammation
Post-translational modifications of histones determines cell lineage- or signal-specific gene expression. Depending on the type and combination of modifications, histones bind to functionally distinct effector proteins ('readers') that control gene activation or silencing. The current pharmacologic...
ORGANISM(S): Mus musculus 
2010-11-10 | E-GEOD-21910 | biostudies-arrayexpress
TranscriptomicsAutism-like syndrome is induced in mice by pharmacological suppression of BET proteins
Studies investigating the causes of autism spectrum disorder (ASD) point to genetic as well as epigenetic mechanisms of the disease. Identification of epigenetic processes that contribute to ASD development and progression is of major importance and may lead to the development of novel therapeutic s...
ORGANISM(S): Mus musculus 
2015-09-09 | E-GEOD-72149 | biostudies-arrayexpress
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