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GenomicsWdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. However, it remains unclear whether components of these networks functionally interact and if so, what factors mediate such interactions. Here we show that WD-repeat protein...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-22934 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse hematopoietic stem cells and other stages of the hematopoietic hierarchy, and to identify the shared expressed genes among the hematopoietic cells and neural and embryonic stem cells in mouse
Study to determine global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy, and to identify the shared expressed genes among the hematopoietic cells and neural and embryonic stem cells in mouse.
ORGANISM(S): Mus musculus 
2007-07-19 | E-CBIL-33 | biostudies-arrayexpress
TranscriptomicsWdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network (2)
The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. It remains unclear whether interactions. Here we show that a core member of the Set/MLL complex, WDrepeat protein-5 (Wdr5), is a novel regulator of self-renewal and partners...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-19588 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profile on hiPSCs and hiPSC-derived CD33+ myeloid cells
To gain insights into which pathways might be dysregulated in JMML, we compared the transcriptome profiles among hiPSC and sorted CD33+ myeloid cells from control and patient samples. NS/JMML-derived CD33+ myeloid cells showed dysregulation in major biological processes. Moreover, a consistent expre...
ORGANISM(S): Homo sapiens 
2014-01-31 | E-GEOD-54538 | biostudies-arrayexpress
TranscriptomicsRegulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling
Illumina Beadchip array analyses of mouse embryonic stem cell gene expression profiles in the presence of or upon knockdown of Aurka. An ES complementation 'rescue' system was employed to measure the effects of knockdown (minus Dox). Aurka was rescued to wildtype levels in the presence of Dox (plus ...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-23541 | biostudies-arrayexpress
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