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ProteomicsPSCK9 knockdown in EndoC-bH1 cells at 72 h (pilot TMT experiment)
EndoC-bH1 cells were incubated with control siRNA or PCSK9 siRNA for 72 hours. Unpowered exploratory experiment. Sample size: 3x3.
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD027921 | Pride
Human Pcsk9 Endoc-bh1 
ProteomicsPSCK9 knockdown in EndoC-bH1 cells at 72 h (DIA secretome experiment)
EndoC-bH1 cells were incubated with control siRNA or PCSK9 siRNA for 72 hours. The experiment was powered based PCSK9 knockdown in the pilot experiment [PXDxxx (PE083)]. Sample size: 12x12.
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD027913 | Pride
Human Pcsk9 Endoc-bh1 
ProteomicsPSCK9 knockdown in EndoC-bH1 cells at 72 h (DIA proteomics experiment)
EndoC-bH1 cells were incubated with control siRNA or PCSK9 siRNA for 72 hours. The experiment was powered based PCSK9 knockdown in a pilot experiment. Sample size: 12x12.
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD027911 | Pride
Human Pcsk9 Endoc-bh1 
ProteomicsEffect of control siRNA knockdown on EndoC-bH1 cell lysate proteome (pilot TMT experiment)
EndoC-bH1 cells proteomics was assessed in untreated baseline condition and after treatment with control siRNA at 24, 48 and 72 hours. Unpowered exploratory experiment. Sample size: triplicate per condition.
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD027898 | Pride
Human Endoc-bh1 
ProteomicsPSCK9 knockdown in EndoC-bH1 cells time course (DIA secretome time course)
EndoC-bH1 cells were incubated with control siRNA or PCSK9 siRNA for 24, 48 and 72 hours. Untreated baseline samples were also included. Unpowered exploratory experiment. Sample size: triplicate per condition.
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD027920 | Pride
Human Pcsk9 Endoc-bh1 
TranscriptomicsTranscriptome profile of human pancreatic beta cell line (EndoC-M-NM-2H2 ) following knockdown of RFX6.
RFX6 is a key transcription factor for the development of mouse pancreas, however the functional roles of RFX6 in human beta cells are poorly explored. Thus transcriptome analysis was perfomed to determine the functional targets of RFX6 in human beta cells using the recently developed human beta cel...
ORGANISM(S): Homo sapiens 
2014-12-22 | E-GEOD-59049 | biostudies-arrayexpress
TranscriptomicsA conditionally immortalized human pancreatic beta cell line
Access to an unlimited number of human pancreatic beta cells represents a major challenge in the field of diabetes to better dissect human beta cell functions and to make significant progress in drug discovery and cell replacement therapies. We previously reported the generation of the EndoC-bH1 hum...
ORGANISM(S): Homo sapiens 
2014-03-21 | E-GEOD-48101 | biostudies-arrayexpress
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