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TranscriptomicsExpression study of the Hodgkin’s lymphoma cell line L-1236 upon CRISPR Cas9-mediated knockout of lymphotoxin alpha (LTA) compared to control
Persistent activation of canonical and non-canonical NF-κB pathways is a hallmark of the malignant Hodgkin and Reed-Sternberg cells in classical Hodgkin lymphoma (cHL). We identified lymphotoxin alpha (LTA), which is secreted by the cHL cell line L-1236 in high concentrations. This cytokine contribu...
ORGANISM(S): Homo sapiens 
2019-01-24 | E-MTAB-6896 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of IKKbeta knockdown EDC4 knockdown irradiated and untreated
U2OS cells expressing DOX inducible pTRIPZ shRNA against IKKbeta or EDC4 were irradiated or left untreated. RNA stability was determined as through actinomycin D chase experiment.
ORGANISM(S): Homo sapiens 
2018-10-29 | E-MTAB-7199 | biostudies-arrayexpress
TranscriptomicsVitamin D3 affects TNFa mediated activation of dendritic cells
The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of N...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-8334 | biostudies-arrayexpress
TranscriptomicsNF-kB target genes in dendritic cells
The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of N...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-8009 | biostudies-arrayexpress
GenomicsGenome wide binding sites of NF-κB subunits RelA, RelB, p50, and p52 in the Hodgkin lymphoma cell line L1236
The malignant cells of Hodgkin's lymphoma are characterized by a constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We carried out genome-wide localization and expression profiling experiments in the Hodgkin lymphoma cell line L1236 for the canonical and...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-63736 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of canonical and non-canonical NF-κB signaling pathways in Hodgkin’s lymphoma
Malignant Hodgkin's lymphoma (HL) cells are characterized by constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We depleted subunit combinations corresponding to either canonical (p50/RelA) or non-canonical (p52/RelB) dimers in the HL cell line L-1236 an...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-64232 | biostudies-arrayexpress
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