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TranscriptomicsBTG1 and BTG2 Regulate B Linege Commitment by Modulation of EBF1 Activity
The human BTG1 and BTG2 genes are targeted by genetic alterations in hematological malignancies. In this study we examined the unique and overlapping functions of Btg1 and Btg2 in mouse B cell development. Mice deficient for Btg1 and Btg2 displayed the strongest phenotype with a decrease in B cell n...
ORGANISM(S): Mus musculus 
2014-03-19 | E-GEOD-55997 | biostudies-arrayexpress
TranscriptomicsBTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia
RNAi mediated knockdown of BTG1 in the acute lymphoblastic cell line RS4;11 causes this cell line to become resistant to prednisolone treatment when compared to control cells. In this experiment we treated BTG1 knockdown RS4;11 cells and control RS4;11 cells either with prednisolone or a vehicle con...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18027 | biostudies-arrayexpress
TranscriptomicsTumor Suppressor IKZF1 Mediates Glucocorticoid Therapy Resistance in B Cell Precursor Acute Lymphoblastic Leukemia
Analysis of the effect of Prednisolone in mouse splenocytes with and without Ikzf1 at gene expression level. The hypothesis tested in the present study was that loss of Ikzf1 affects the induction and repression of the Glucocorticoid receptor target genes. Results provide important information of th...
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-65554 | biostudies-arrayexpress
TranscriptomicsBTG1 modulates ATF4 function in response to cellular stress: implications for tumor cell survival
Analysis of the effect of glutamine starvation in mouse embryonic fibroblasts (MEFs) with and without Btg1 at gene expression level. The hypothesis tested in the present study was that loss of Btg1 affect the expression of stress-response genes. Results provide important information of the different...
ORGANISM(S): Mus musculus 
2014-11-26 | E-GEOD-63642 | biostudies-arrayexpress
TranscriptomicsLoss of BTG1 function promotes ETV6-RUNX1-mediated leukemic transformation by upregulation of BCL6
Analysis of gene signatures in WT+Ctrl vs WT+ETV6-RUNX1, Btg1-/- and Btg1-/-+ETV6-RUNX1 in cKit+Ter119- fetal liver-derived hematopoietic progenitor cells (FL-HPCs). The Btg1-/-+ETV6-RUNX1 FL-HPCs display a strong increase in proliferation compared to WT+ETV6-RUNX1. Total RNA otained from WT+Ctrl, W...
ORGANISM(S): Mus musculus 
2014-08-22 | E-GEOD-60589 | biostudies-arrayexpress
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