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TranscriptomicsAndrogen and Glucocorticoid stimulation of LREX' cells in vitro
The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Using the LnCaP/AR xenograft model, we identified induction of glucocorticoid receptor (GR) expression as a common feature of drug resistant tumors. From a resistant xenograft tumor...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51871 | biostudies-arrayexpress
TranscriptomicsLNCAP/AR and a LnCAP/AR subline (LREX') with acquired resistance to 2nd generation antiandrogens
The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Using the LnCaP/AR xenograft model, we identified induction of glucocorticoid receptor (GR) expression as a common feature of drug resistant tumors. From a resistant xenograft tumor...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51873 | biostudies-arrayexpress
GenomicsGlucocorticoid Receptor and Androgen Receptor DNA binding in LREX'
LREX' are a LnCAP/AR subline with natural expresison of the glucocorticoid receptor. We used the model to compare the AR and GR cistromes in prostate tissue. We determined the GR cistrone in the presence of Dex (100nM) treatment and the AR cistrome in the presene of DHT (1nM) treatment.
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51497 | biostudies-arrayexpress
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