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ProteomicsDevelopment of an In Vitro Metabolic Dysfunction-Associated Steatohepatitis Model to Investigate Altered Drug Metabolizing Enzymes, Transport Proteins, and Hepatobiliary Disposition
Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect approximately 30% of adults worldwide. The progressive form of MASLD, namely metabolic-dysfunction steatohepatitis (MASH), is a leading cause of chronic liver disease. MASH is marked by hepatocellular fat accumul...
ORGANISM(S): Homo sapiens (Human) 
2025-12-12 | PXD071083 | Pride
Human Lc-msms Schh Mash 
UnknownPregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression.
Not available
S-EPMC7750305 | biostudies-literature
UnknownHepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes.
Not available
S-EPMC4885486 | biostudies-literature
UnknownEarly identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).
Not available
S-EPMC3858191 | biostudies-literature
UnknownRole of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions.
Not available
S-EPMC7357176 | biostudies-literature
UnknownDevelopment of an in vitro metabolic dysfunction-associated steatohepatitis model to investigate altered drug metabolizing enzymes, transport proteins, and hepatobiliary disposition.
Not available
S-EPMC12832903 | biostudies-literature
UnknownEvaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters.
Not available
S-EPMC12804587 | biostudies-literature
UnknownPregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam.
Not available
S-EPMC10354249 | biostudies-literature
UnknownImpact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes.
Not available
S-EPMC9532936 | biostudies-literature
UnknownComparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models.
Not available
S-EPMC5723701 | biostudies-literature
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