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ProteomicsSynergistic efficacy of combined SUMOylation and proteasome inhibition in multiple myeloma
Relapsed/refractory multiple myeloma (r/r MM) is a disease with often poor prognosis. Hyperactive SUMO signaling is involved in both cancer pathogenesis and cancer progression. A state of increased SUMOylation has been associated with aggressive cancer biology. Here, we found that r/r MM is characte...
ORGANISM(S): Homo sapiens (Human) 
2022-08-01 | PXD032316 | Pride
Proteasome inhibitor Myeloma Sumoylation inhibitor 
UnknownSUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma.
Not available
S-EPMC9979771 | biostudies-literature
ProteomicsActivated SUMOylation restricts the MHC class I antigen presentation pathway to confer immune evasion in cancer
Activated SUMOylation is a hallmark of aggressive cancers. Starting from a targeted screening for SUMO-regulated immune evasion mechanisms, we identified an evolutionary conserved function of activated SUMOylation, which attenuates the immunogenicity of tumor cells. Activated SUMOylation allows canc...
ORGANISM(S): Homo sapiens (Human) 
2022-01-15 | PXD030506 | Pride
Human B-cell lymphoma 
UnknownActivated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Not available
S-EPMC9057585 | biostudies-literature
UnknownAssociation of exome sequences with plasma C-reactive protein levels in >9000 participants.
Not available
S-EPMC4334838 | biostudies-literature
UnknownUnderstanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways.
Not available
S-EPMC9402243 | biostudies-literature
UnknownRare coding variants and X-linked loci associated with age at menarche.
Not available
S-EPMC4538850 | biostudies-literature
UnknownPlatelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.
Not available
S-EPMC5005441 | biostudies-literature
UnknownLarge-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
Not available
S-EPMC4661791 | biostudies-literature
UnknownGenome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Not available
S-EPMC6218410 | biostudies-literature
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