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TranscriptomicsTranscription profiling of mouse ventricles of IGF1R, IGF1R-caPI3K, IGF1R-dnPI3K, caPI3K, dnPI3K transgenic female mice at 3 months of age vs. non transgenic littermate controls
IGF1 and IGF1 receptors (IGF1R) are present in the adult heart and have been shown to be essential for myocardial performance. Insulin-like growth factor 1 (IGF1) is produced in numerous tissues particularly by the liver in response to growth hormone stimulation and is an important factor in the reg...
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1143 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart samples from animals with physiological or pathological cardiac hypertrophy
Dahl salt-sensitive (DS) rats were obtained from Harlan Sprague Dawley Laboratory at 5 weeks of age. At 6 weeks of age, physiologic cardiac hypertrophy was generated by a; vigorous daily exercise regimen for 6 weeks (e group). The exercise protocol is based on those described previously with modific...
ORGANISM(S): Rattus norvegicus 
2007-10-11 | E-GEOD-776 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hearts from Nkx2.5 knockout mice (mouse model of congenital heart disease) at embryonic day 12.5 shows Nkx2.5 is not only crucial during early steps of cardiogenesis but also plays an important role at later developmental stages
The NK2 family of homeobox genes constitutes a family of transcription factors that play an important role in different developmental processes. Members of this group are characterized by two highly conserved protein domains: the homeodomain, conferring DNA binding activity, and the NK2-specific dom...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-528 | biostudies-arrayexpress
Transcriptomicschanges in cardiac transcription profiles brought about by heart failure
To establish changes in cardiac transcription profiles brought about by heart failure we collected myocardial samples from patients undergoing cardiac transplantation whose failure arises from different etiologies (e.g. idiopathic dilated cardiomyopathy, ischemic cardiomyopathy, alcoholic cardiomyop...
ORGANISM(S): Homo sapiens 
2004-03-24 | E-GEOD-1145 | biostudies-arrayexpress
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