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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
UnknownA novel locus (DFNA24) for prelingual nonprogressive autosomal dominant nonsyndromic hearing loss maps to 4q35-qter in a large Swiss German kindred.
Not available
S-EPMC1288211 | biostudies-literature
TranscriptomicsEpigenetic Control of Light-Regulated Gene Expression in Arabidopsis
Although landscapes of several epigenetic marks are now available for Arabidopsis and rice, such profiles remain static and do not provide information about dynamic changes of plant epigenomes in response to developmental or environmental cues. Here we analyzed the effects of light regulation on fou...
ORGANISM(S): Arabidopsis thaliana 
2009-12-30 | E-GEOD-15597 | biostudies-arrayexpress
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
GenomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [ChIP-seq]
Children with Down syndrome (DS) have a 20-fold increased risk of developing B cell acute lymphoblastic leukemia (B-ALL). Polysomy 21 (i.e., extra copies of chr.21) is also the most frequent somatic aneuploidy among all B-ALLs. Additional B-ALLs harbor intrachromosomal amplifications of chr.21q22 (i...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48534 | biostudies-arrayexpress
TranscriptomicsCopy number variation analysis of hepatic metastases from uveal melanoma
Metastatic uveal melanoma (MUM) is chemoresistant and usually fatal within one year of diagnosis. There is an urgent need to better understand disease pathogenesis, in order to determine key drivers of the metastatic process that could be effectively targeted by therapy. Gene copy number variations ...
ORGANISM(S): Homo sapiens 
2016-05-18 | E-GEOD-69614 | biostudies-arrayexpress
UnknownPhenotypic characterization of DFNA24: prelingual progressive sensorineural hearing impairment.
Not available
S-EPMC2923580 | biostudies-literature
TranscriptomicsTranscription profiling of H2O2 treated rat cardiac myocytes
Title: Changes in gene expression affected by H2O2 in cardiac myocytes.
Description: We aim to identify the changes in gene expression in response to
oxidative stress in rat neonatal ventricular myocytes.
Oxidative stress will be induced by dosing neonatal ventricular myocyte...
ORGANISM(S): Rattus norvegicus 
2011-11-08 | E-MIMR-12 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human nasal brushing cells from 19 cystic fibrosis (CF) patients and 19 healthy controls
We have compared gene expression in human nasal brushing cells from 19 cystic fibrosis (CF) patients and 19 healthy controls using a 5.2K cDNA microarray. Our aim is to identify new disease biomarkers for the Cystic Fibrosis Gene Therapy Consortium. These markers will be used to report more effectiv...
ORGANISM(S): Homo sapiens 
2011-04-30 | E-MEXP-436 | biostudies-arrayexpress
UnknownTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.
Not available
S-EPMC4040006 | biostudies-literature
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