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ProteomicsIdentification of a damaging variant rs35033974 associated with idiopathic male infertility through degradation of TEX101 protein and its transient interactome
Human TEX101 is a testis-specific cell membrane protein expressed exclusively in male germ cells and a validated biomarker of male infertility. TEX101 was suggested to function as a cell surface chaperone of numerous proteins involved in sperm migration and sperm-egg interaction. However, the precis...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD008333 | Pride
A disintegrin and metalloproteinase domain-containing protein 29  interactome  testis-specific proteins  spermatozoa  single nucleotide polymorphism (snp)  deleterious variant  unexplained infertility Tex101  testis-expressed sequence 101 protein  ly6k  lymphocyte antigen 6 complex Locus k  adam29 
ProteomicsDiscovery of a testis-specific complex TEX101-DPEP3 and selection of its disrupting antibodies
TEX101 is a testis-specific protein expressed exclusively in male germ cells and is a validated biomarker of male infertility. Studies in mice suggest that TEX101 is a cell-surface chaperone which regulates, through protein-protein interactions, the maturation of proteins involved in spermatozoa tra...
ORGANISM(S): Homo sapiens (Human) 
2018-08-16 | PXD007515 | Pride
Tex101  testis-expressed sequence 101 protein  dpep3  dipeptidase 3  affinity purification-mass spectrometry  interactome  protein-protein interactions  testis-specific proteins  spermatozoa  disrupting antibodies 
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