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TranscriptomicsTranscriptional profiling of human in vitro primed Th1, Th2, Th9 and Treg T cells
To test whether human in vitro primed Th9 cells recapitulate the core pathogenic Th2 cell phenotype, we differentiated naïve T cells into Th1 (IL-12), Th2 (IL-4), Th9 (IL-4+TGF-β), and iTreg (TGF-β). After 7 days transcriptomic profiling by bulk RNA-seq was performed.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12199 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of non-lesional and lesional human skin of positive patch-test reactions to nickel at 24h, 48h, and 120h post allergen application
Donor-matched human skin biopsies were taken from non-lesional (NL) and lesional skin of positive patch-test reactions to nickel at 24h, 48h, and 120h post allergen application, respectively, and bulk RNA-seq was performed.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12237 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human Th9 T cell clones treated with GW9662 against untreated control
To investigate the role of PPAR-γ in human TH cells, transcriptional response of activated “TH9” clones to treatment with GW9662, a potent PPAR-γ antagonist was assessed. “TH9” cell clones were incubated with GW9662 for 48h and activated with αCD3/2/28 for 12 h. Transcriptomic profiling was performe...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12197 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human IL-9R+ T helper cells in presence of recombinant IL-9 against untreated control
To study the effect of paracrine interleukin-9 (IL-9) on T helper cells, we incubated IL-9R+ T helper cells isolated from blood (5 samples) and skin (3 samples) with or without IL-9 for 12h and the transcriptome was analyzed by bulk RNA-seq.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12204 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Th1, Th2, Th9, and Th17 T cell clones
We next sought to identify the transcriptional program that differentiates IL-9+Th2 cells from “conventional” Th2 cells. To this end, we selected representative Th1, Th17, Th2, and IL-9+Th2 clones (Figure 5A) and determined their transcriptome in the resting state and at different time points after ...
ORGANISM(S): Homo sapiens 
2017-11-10 | E-MTAB-5739 | biostudies-arrayexpress
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