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TranscriptomicsUbiquinol-induced gene expression signatures are translated into reduced erythropoiesis and LDL cholesterol levels in humans
Studies in vitro and in mice indicate a role for Coenzyme Q10 (CoQ10) in gene expression. To determine this function in relationship to physiological readouts, a 2-week supplementation study with the reduced form of CoQ10 (ubiquinol, Q10H2, 150 mg/d) was performed in 53 healthy males. Mean CoQ10 pla...
ORGANISM(S): Homo sapiens 
2013-04-08 | E-GEOD-21351 | biostudies-arrayexpress
TranscriptomicsCoenzyme Q10-dependent gene expression in SAMP1 mice tissues
Our present study reveals significant decelerating effects on senescence processes in middle-aged SAMP1 mice supplemented for 6 or 14 months with the reduced form (QH2, 500 mg/ kg BW/ day) of coenzyme Q10 (CoQ10). To unravel molecular mechanisms of these CoQ10 effects, a genome-wide transcript profi...
ORGANISM(S): Mus musculus 
2010-03-15 | E-GEOD-15129 | biostudies-arrayexpress
TranscriptomicsIdentification of LPS-inducible genes down-regulated by ubiquinone in human THP-1 cells
Coenzyme Q10 (CoQ10) is an obligatory element in the respiratory chain and functions as a potent antioxidant of lipid membranes. More recently, anti-inflammatory effects as well as an impact of CoQ10 on gene expression have been observed. To reveal putative effects of Q10 on LPS-induced gene express...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-19625 | biostudies-arrayexpress
TranscriptomicsThe reduced form of Coenzyme Q10 decreases the expression of LPS-sensitive genes in human THP-1 cells
Monocytes are key players in inflammatory processes which are triggered by lipopolysaccharide (LPS), the major outer membrane component of gram-negative bacteria. The present study in human monocytic THP-1 cells was designed in order to identify LPS-inducible genes which are down-regulated by the re...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-19627 | biostudies-arrayexpress
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