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MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
TranscriptomicsGene expression analysis of ER-stressed growth plate chondrocytes in two mouse models of Schmid chondrodysplasia
We set out to generate transcriptional maps of chondrocyte UPR gene networks in vivo using two mouse models (Schmid and Cog) of Schmid chondrodysplasia, in order to define the consequences of UPR activation for the adaptation, differentiation, and survival of chondrocytes experiencing ER stress duri...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-30628 | biostudies-arrayexpress
TranscriptomicsTwo transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [gene expression data]
Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments...
ORGANISM(S): Halobacterium sp. NRC-1 
2011-06-03 | E-GEOD-29704 | biostudies-arrayexpress
TranscriptomicsSystematic analysis of a human renal transcript dataset
Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function. Quite a few of these genes show a specific or preferential mRNA expression in the renal glomerulus. To identify additional candidate genes ...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-21785 | biostudies-arrayexpress
MetabolomicsImpact of shear stress and moderate electric field on the global metabolic profile of a blended fruit and vegetable juice
This study investigated the impact of moderate electric field (MEF) and shear stress (SS) on the chemical profile of a blended fruit and vegetable juice using untargeted metabolomics. Samples underwent mild thermal treatment, MEF, and a combination of MEF and SS, with subsequent chemical changes ana...
2025-09-30 | MTBLS11719 | MetaboLights
TranscriptomicsTwo transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [ChIP-chip data]
Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments...
ORGANISM(S): Halobacterium sp. NRC-1 
2011-06-02 | E-GEOD-29705 | biostudies-arrayexpress
TranscriptomicsAnalysis of the IRE1/XBP1 unfolded protein response (UPR) pathway in Schmid metaphyseal chondrodysplasia hypertrophic chondrocyte endoplasmic reticulum (ER) stress
We set out to determine the role of the IRE1/XBP1 pathway, the most ancient and highly conserved endoplasmic reticulum (ER) stress-sensing pathway of the unfolded protein response (UPR), in Schmid metaphyseal chondrodysplasia (MCDS). RNA derived from hypertrophic zones microdissected from growth pla...
ORGANISM(S): Mus musculus 
2015-08-21 | E-GEOD-72261 | biostudies-arrayexpress
TranscriptomicsRosR is a haloarchaeal-specific transcription factor required for the response to extreme oxidative stress in Halobacterium salinarum NRC-1.
Previous work has shown that the hypersaline-adapted archaeon, Halobacterium salinarum NRC-1, is highly resistant to oxidative stress caused by exposure to hydrogen peroxide, UV and gamma radiation. Genome-wide dynamics alteration of gene the GRN has been implicated in such resistance. However, the...
ORGANISM(S): Halobacterium sp. NRC-1 
2012-08-12 | E-GEOD-33980 | biostudies-arrayexpress
TranscriptomicsTwo transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon
This SuperSeries is composed of the following subset Series: GSE29704: Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [gene expression data] GSE29705: Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [ChIP-chip data] R...
ORGANISM(S): Halobacterium sp. NRC-1 
2011-06-02 | E-GEOD-29706 | biostudies-arrayexpress
MetabolomicsUncovering the secrets of monoculture yield decline: Trade-offs between leaf and root chemical and physical defence traits in a grasslands experiment

Plant monocultures growing for extended periods face severe losses of productivity. This phenomenon, known as 'yield decline', is often caused by the accumulation of above- and below-ground plant antagonists. The effectiveness of plant defences against antagonists might help explain differences i...

2023-11-03 | MTBLS4286 | MetaboLights
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