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TranscriptomicsGene expression analysis of ER-stressed growth plate chondrocytes in two mouse models of Schmid chondrodysplasia
We set out to generate transcriptional maps of chondrocyte UPR gene networks in vivo using two mouse models (Schmid and Cog) of Schmid chondrodysplasia, in order to define the consequences of UPR activation for the adaptation, differentiation, and survival of chondrocytes experiencing ER stress duri...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-30628 | biostudies-arrayexpress
UnknownA new feeding group within larval Drusinae (Trichoptera: Limnephilidae): the alpinus-group sensu Schmid, 1956, including larval descriptions of Drusus franzi Schmid, 1956 and Drusus alpinus (Meyer-Dur, 1875).
Not available
S-EPMC4826607 | biostudies-literature
TranscriptomicsAnalysis of the IRE1/XBP1 unfolded protein response (UPR) pathway in Schmid metaphyseal chondrodysplasia hypertrophic chondrocyte endoplasmic reticulum (ER) stress
We set out to determine the role of the IRE1/XBP1 pathway, the most ancient and highly conserved endoplasmic reticulum (ER) stress-sensing pathway of the unfolded protein response (UPR), in Schmid metaphyseal chondrodysplasia (MCDS). RNA derived from hypertrophic zones microdissected from growth pla...
ORGANISM(S): Mus musculus 
2015-08-21 | E-GEOD-72261 | biostudies-arrayexpress
UnknownMethods for aligning and for averaging 3D volumes with missing data.
Not available
S-EPMC2680136 | biostudies-literature
TranscriptomicsTwo transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [gene expression data]
Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments...
ORGANISM(S): Halobacterium sp. NRC-1 
2011-06-03 | E-GEOD-29704 | biostudies-arrayexpress
GenomicsStudy of RFX1 and RFX3 binding sites in the mouse genome
The aim of the study was to identify RFX1 and RFX2 binding sites in mouse pancreatic beta cells. Chromatin immunoprecipitation experiments were performed with the mouse MIN6 beta cell line and antibodies raised against RFX1 and RFX3. Immunoprecipitated DNA was sequenced using the Genome Analyzer II ...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-72272 | biostudies-arrayexpress
TranscriptomicsRosR is a haloarchaeal-specific transcription factor required for the response to extreme oxidative stress in Halobacterium salinarum NRC-1.
Previous work has shown that the hypersaline-adapted archaeon, Halobacterium salinarum NRC-1, is highly resistant to oxidative stress caused by exposure to hydrogen peroxide, UV and gamma radiation. Genome-wide dynamics alteration of gene the GRN has been implicated in such resistance. However, the...
ORGANISM(S): Halobacterium sp. NRC-1 
2012-08-12 | E-GEOD-33980 | biostudies-arrayexpress
UnknownClinical, Molecular Characteristics, and Genotype-Phenotype Relationships of Metaphyseal Chondrodysplasia Type Schmid.
Not available
S-EPMC12743679 | biostudies-literature
TranscriptomicsChromosome-wide mapping of interactions of yeast nucleoporin Nup2 on chromosome VI.
This series is a complementary data set for the manuscript entitled "Nup-PI: The Nucleopore-Promoter Interactions of Genes in Yeast." (Mol. Cell, 2006). Experimental Background: Genomic interaction sites of nuclear proteins were mapped by the in vivo ChEC technique described in Schmid et al. (2004)...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-3756 | biostudies-arrayexpress
TranscriptomicsH. salinarum TrmB dynamics
Previous work characterized TrmB as a global glucose responsive metabolic transcription factor in archaeal extremophiles. However, it remains unclear how TrmB dynamically regulates its ~100 metabolic enzyme-coding genes. Using a dynamic perturbation approach, we elucidate the topology of the metabol...
ORGANISM(S): Halobacterium sp. NRC-1 
2013-08-07 | E-GEOD-47201 | biostudies-arrayexpress
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