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TranscriptomicsExpression data from wild type and globally hypomethylated mouse embryonic stem cells (ESCs) during their differentiation as embyroid bodies
To analyze the role of DNA methylation during differentiation, we performed genome-wide expression analysis of undifferentiated wild type, dnmt1-/- and triple knock out (TKO; dnmt1-/-, dnmt3a-/-, dnmt3b-/-) ESCs as well as respective embryoid bodies (EBs) at two stages of differentiation We generate...
ORGANISM(S): Mus musculus 
2013-02-05 | E-GEOD-36679 | biostudies-arrayexpress
ProteomicsDiscovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease - 2nd cohort
In order to identify differentially abundant proteins, human plasma samples from COVID-19 patients with either a mild or moderate (MM) or a critical or severe (CS) disease course from acute phase of infection were analyzed on antibody microarrays 998 different proteins by 1,425 antibodies.
ORGANISM(S): Homo sapiens 
2023-03-15 | E-MTAB-12777 | biostudies-arrayexpress
GenomicsChIP-Seq analysis of CCCTC-binding factor (CTCF) binding in rodents
We explored the microevolutionary trends of CTCF binding evolution by preforming ChIP-seq experiments in five closely related Mus strains, subspecies and species: Mus musculus domesticus, Mus musculus castaneus, Mus spretus, Mus caroli and Mus pahari. All experiments were performed in adult male liv...
ORGANISM(S): Mus musculus domesticus 
2018-03-06 | E-MTAB-5769 | biostudies-arrayexpress
ProteomicsDiscovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease - 1st cohort
In order to identify differentially abundant proteins, human plasma samples from COVID-19 patients with either a mild or moderate (MM) or a critical or severe (CS) disease course from the acute phases of infection were analyzed on antibody microarrays targeting 351 different proteins by 517 antibodi...
ORGANISM(S): Homo sapiens 
2023-04-11 | E-MTAB-12779 | biostudies-arrayexpress
GenomicsTranscriptionally active chromatin channels DNA double-strand breaks to RAD51-dependent repair
Cells have developed effective mechanisms, namely homologous recombination (HR) and non-homologous end-joining (NHEJ), to repair DNA double-strand breaks (DSBs), which are considered to be the most deleterious type of damage that can challenge genome integrity. While these pathways coexist to repair...
ORGANISM(S): Homo sapiens 
2014-03-23 | E-MTAB-1241 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
The synthetic lethal relationship between MYC and SAE2 has been previously described in FC-MYC cells using RNAi (Littler et al., 2019). Building on this work, we conducted transcriptomic analysis on MYC-low and MYC-high cells following inhibition of SUMOylation with the SAE1/2 inhibitor, ML-792 (SAE...
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14654 | biostudies-arrayexpress
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