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GenomicsCHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
Gene expression changes were measured between mouse ES cells of three genotypes: WT Chd7, Heterzygous Chd7 Null, Homozygous Chd7 Null. The hypothesis being tested was that CHD7, a chromatin remodeling protein, functions as a transcriptional regulator. This experiment was performed to detect gene t...
ORGANISM(S): Mus musculus 
2010-06-15 | E-GEOD-22341 | biostudies-arrayexpress
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-30407 | biostudies-arrayexpress
TranscriptomicsIndividual susceptibility to chronic stress is modulated by AMPA receptor function
Chronic stress is a key risk factor for a variety of diseases, but the determinants of individual stress susceptibility are still unclear. Using a recently developed paradigm for chronic social stress in mice we identified animals that were resistant or susceptible to the persistent effects of chron...
ORGANISM(S): Mus musculus 
2010-10-25 | E-GEOD-11211 | biostudies-arrayexpress
TranscriptomicsInvestigating the first genomic response to stress – insights into the etiology and pathophysiology of major depression
While exposure to adverse life events and subsequent dysregulation of the stress hormone response broadly confer risk for depression, the specific molecular mechanisms mediating this risk are poorly understood. Through pharmacologic activation of the stress hormone response in blood cells we demonst...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-46743 | biostudies-arrayexpress
UnknownGlobal, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Not available
S-EPMC6227755 | biostudies-literature
UnknownGenome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
Not available
S-EPMC6713272 | biostudies-literature
UnknownThe African Critical Illness Outcomes Study (ACIOS): a point prevalence study of critical illness in 22 nations in Africa.
Not available
S-EPMC11872788 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
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