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TranscriptomicsComplete Haplotype Phasing of the MHC and KIR Loci with Targeted HaploSeq
Rapid advances in biochemical technologies have enabled several strategies for typing candidate HLA alleles, but linking them into a single MHC haplotype structure remains challenging. Here we have developed a multi-loci haplotype phasing technique and demonstrate its utility towards phasing of MHC ...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-GEOD-65726 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis of haplotype-resolved epigenomes across human tissues
Allelic differences between the two sets of chromosomes can affect the propensity of inheritance in humans, but the extent of such differences in the human genome has yet to be fully explored. Here, we delineate allelic chromatin modifications and transcriptomes amongst a broad set of human tissues...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-58752 | biostudies-arrayexpress
TranscriptomicsA sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzyma...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-34055 | biostudies-arrayexpress
ProteomicsTaf2 mediates DNA binding of Taf14
The assembly and function of the yeast general transcription factor TFIID complex requires specific contacts between its Taf14 and Taf2 subunits, however, the mechanism underlying these contacts remains unclear. Here, we determined the molecular and structural basis by which the YEATS and ET domains...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-12 | PXD033397 | Pride
Taf2 mediates dna binding of taf14 
UnknownMetabolic, Molecular, and Behavioral Effects of Western Diet in Serotonin Transporter-Deficient Mice: Rescue by Heterozygosity?
Not available
S-EPMC7041415 | biostudies-literature
UnknownTaf2 mediates DNA binding of Taf14.
Not available
S-EPMC9177701 | biostudies-literature
TranscriptomicsYeast (Saccharomyces cerevisiae) Overexpression suppression study
To address the mechanisms of suppression, we analyzed time course of mRNA expression of four suppressed smc2-8 mutant strains. We addressed the question of genomic robustness by systematically screening genomic open reading frames, when induced for high-level expression, for their ability to suppres...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-20 | E-GEOD-24266 | biostudies-arrayexpress
UnknownCost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine coronary computed tomography angiography.
Not available
S-EPMC12187117 | biostudies-literature
UnknownConstructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.
Not available
S-EPMC9417284 | biostudies-literature
UnknownBenchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis: Implications for Severely Calcified Coronaries.
Not available
S-EPMC7618422 | biostudies-literature
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