Sort   by:  
 Page size 
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia coli 
2019-10-22 | PXD010174 | Pride
Macrocyclic peptidomimetic antibiotics Novel molecular mode of action Lpt complex E.coli Dda Ompta (outer membrane-targeting antibiotics) Lc-ms/ms Bam complex Photoaffinity labeling Thermo q-exactive plus Interaction mapping Photo crosslinking Gram-negative eskape pathogens 
ProteomicsEndosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity
Multi-epitope affinity purification mass spectrometry (meAP-MS) analysis of TMEM9-, TMEM9B- and CLC3- associated proteins from solubilized mouse brain membranes identified chloride channel subtypes CLCN3, 4 and 5 as exclusive interaction partners of TMEM9 and TMM9B.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD061285 | Pride
Ap-ms Chloride channels Membrane protein complex Auxiliary subunits Mouse brain Protein-protein interactions 
TranscriptomicsInstruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model
The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pa...
ORGANISM(S): Mus musculus 
2013-10-15 | E-MTAB-1820 | biostudies-arrayexpress
UnknownAssociation of intraoperative end-tidal CO<sub>2</sub> levels with postoperative outcomes: a patient-level analysis of two randomised clinical trials.
Not available
S-EPMC12799414 | biostudies-literature
Sort   by:  
 Page size