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TranscriptomicsInhibitor of NFκB ζ (IκBζ) is a transcriptional key regulator of monocyte chemoattractant protein-1 (MCP-1/CCL2)
Monocyte chemoattractant protein 1 (MCP-1/CCL2) is critically involved in directing the migration of blood monocytes to sites of inflammation. Consequently, excessive MCP-1 secretion has been linked to many (auto)inflammatory diseases, whereas a lack of expression severely impairs immune responsiven...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43075 | biostudies-arrayexpress
ProteomicsTIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells.
Immunotherapies against brain metastases have shown clinical benefits mainly when applied to locally asymptomatic patients. It is currently unclear why responses to this therapy drop in symptomatic brain metastases, since the use of corticoids is not consistently involved. We report here that a subp...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-27 | PXD040436 | Pride
Microenvironment Brain metastasis Immunotherapy 
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 II
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64237 | biostudies-arrayexpress
UnknownTIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells.
Not available
S-EPMC11726018 | biostudies-literature
TranscriptomicsCyclin-dependent kinase 6 is a chromatin-bound cofactor for nuclear factor kappaB-dependent gene expression [Agilent]
Given the intimate link between inflammation and dysregulated cell proliferation in cancer we investigated cytokine-triggered gene expression in different cell cycle stages. High density microarray analysis revealed that G1 release primes and cooperates with the cytokine-driven gene response. This e...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-52465 | biostudies-arrayexpress
TranscriptomicsThe activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65 I
The inflammatory gene response requires activation of the protein kinase TAK1, but it is currently unknown how TAK1-derived signals coordinate transcriptional programs in the genome. We determined the genome-wide binding of the TAK1-controlled NF-M-NM-:B subunit p65 in relation to active enhancers a...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-64201 | biostudies-arrayexpress
UnknownGenome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.
Not available
S-EPMC6288131 | biostudies-literature
UnknownAssessing the genetic association between vitamin B6 metabolism and genetic generalized epilepsy.
Not available
S-EPMC6796782 | biostudies-literature
UnknownBasal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology.
Not available
S-EPMC5097157 | biostudies-literature
UnknownGWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture.
Not available
S-EPMC10484785 | biostudies-literature
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