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TranscriptomicsRNAi profiling of Drosophila SL2 cells knocked down for ISWI
Profiling of changes in steady state RNA levels upon RNAi-mediated knockdown of the nucleosome remodeling ATPase ISWI in Drosophila SL2 cells. Quantitation of the corresponding proteomes has been performed to describe transcriptome-proteome relations. The analysis indicates a limited correlation of ...
ORGANISM(S): Drosophila melanogaster 
2008-10-25 | E-GEOD-11164 | biostudies-arrayexpress
TranscriptomicsJIL-1 RNAi in Drosophila S2 Cells
Profiling of changes in steady state RNA levels upon RNAi-mediated knockdown of the chromosomal kinase JIL-1 in Drosophila S2 cells. Drosophila S2 cells were incubated 7 days after treatment with 10 µg of dsRNA directed against GST/EGFP or JIL-1, respectively. 5 biological replicates per target have...
ORGANISM(S): Drosophila melanogaster 
2011-02-01 | E-GEOD-22620 | biostudies-arrayexpress
TranscriptomicsDifferential Chromatin Binding of the Drosophila Dosage Compensation Complex
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2012-12-11 | E-GEOD-37865 | biostudies-arrayexpress
TranscriptomicsJIL kinase – marker of active chromatin and sensor of dosage compensation
ChIP-chip profiles of JIL-1, H3S10phK14ac and H4K16ac in Drosophila S2 cells JIL-1, H3S10phK14ac and H4K16ac ChIP in Drosophila S2 cells. 2-4 biological replicates per experiment. dye-swaps as indicated in sample description
ORGANISM(S): Drosophila melanogaster 
2011-02-01 | E-GEOD-22618 | biostudies-arrayexpress
TranscriptomicsChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells
ChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells MLE, MSL3 amd MOF ChIP in Drosophila S2 cells. 1-5 biological replicates per experiment. dye-swaps as indicated in sample description
ORGANISM(S): Drosophila melanogaster 
2012-12-11 | E-GEOD-37863 | biostudies-arrayexpress
TranscriptomicsSuv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic c...
ORGANISM(S): Xenopus laevis 
2013-02-06 | E-GEOD-41256 | biostudies-arrayexpress
TranscriptomicsEffects of FSH knockdown on gene expression
see Super Series Summary Gene expression profiles of Drosophila S2-DRSC FSH knockdown cells were generated by Illumna RNA sequencing and compared to profiles derived from control cells (eGFP knockdown).
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-43180 | biostudies-arrayexpress
TranscriptomicsJIL kinase - marker of active chromatin and sensor of dosage compensation
ChIP-chip profiles of RNA Polymerase II phosphorylated on serine 2 in Drosophila S2 cells. RNA Polymerase II phosphorylated on serine 2 ChIP in Drosophila S2 cells. 3 biological replicates with dye-swaps.
ORGANISM(S): Drosophila melanogaster 
2012-05-07 | E-GEOD-37784 | biostudies-arrayexpress
TranscriptomicsAmplification and overexpression of vinculin are associated with increased tumor cell proliferation and progression in advanced prostate cancer
We analyzed the 10q22 amplification in advanced prostate cancer and subjected the genes located in the common amplified region to an RNAi screen. We found vinculin as the most promising candidate gene and analyzed its protein expression on more than 400 prostate cancers by using the tissue micrarray...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-24216 | biostudies-arrayexpress
TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
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