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GenomicsRelapsed and Primary Neuroblastoma DAC
Data Access Committee EGAC00001000373
EGAC00001000373 | EGA
UnknownP38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg.
CD4+CD25+ regulatory T cells (Treg) are important mediators of immune tolerance. A subset of Treg can be generated in the periphery by TGF-beta dependent conversion of conventional CD4+CD25- T cells into induced Treg (iTreg). In chronic viral infection or malignancy, such induced iTreg, which limit ...
S-EPMC2553190 | biostudies-literature
UnknownShort-term mortality prediction in acute pulmonary embolism: Radiomics values of skeletal muscle and intramuscular adipose tissue.

Background

Acute pulmonary embolism (APE) is a potentially life-threatening disorder, emphasizing the importance of accurate risk stratification and survival prognosis. The exploration of imaging biomarkers that can reflect patient survival holds the potential to further enhance the stratifi...
S-EPMC11294025 | biostudies-literature
UnknownAcid sphingomyelinase promotes SGK1-dependent vascular calcification.
In chronic kidney disease (CKD), hyperphosphatemia is a key factor promoting medial vascular calcification, a common complication associated with cardiovascular events and high mortality. Vascular calcification involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs)...
S-EPMC7859357 | biostudies-literature
ProteomicsIncreased levels of the mitochondrial import factor Mia40 can prevent the aggregation of polyQ proteins in the cytosol
The formation of protein aggregates is a hallmark of neurodegenerative diseases. Observations on patient material and model systems demonstrated links between aggregate formation and declining mitochondrial functionality, but the causalities remained unclear. We used yeast as model system to analyze...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-05 | PXD023902 | Pride
Huntingtin / mia40 / mitochondria / protein aggregation / protein translocation 
UnknownA20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
A20 is a ubiquitin-modifying protein that negatively regulates NF-κB signaling. Mutations in A20/TNFAIP3 are associated with a variety of autoimmune diseases, including multiple sclerosis (MS). We found that deletion of A20 in central nervous system (CNS) endothelial cells (ECs) enhances experimenta...
S-EPMC10721159 | biostudies-literature
UnknownEvolution of melanoma cross-resistance to CD8+ T cells and MAPK inhibition in the course of BRAFi treatment.
The profound but frequently transient clinical responses to BRAFV600 inhibitor (BRAFi) treatment in melanoma emphasize the need for combinatorial therapies. Multiple clinical trials combining BRAFi and immunotherapy are under way to further enhance therapeutic responses. However, to which...
S-EPMC6136878 | biostudies-literature
UnknownImpact of Handling Perception and Language Barriers on Virologic Response to Daily Subcutaneous Bulevirtide in Hepatitis D.

Background

Bulevirtide (BLV) is the only approved therapy for chronic hepatitis D (CHD) and compensated liver disease. Daily subcutaneous injection and the need for refrigeration may pose challenges, especially in patients with limited language proficiency.

Aims

Assessment of patient-...
S-EPMC12535276 | biostudies-literature
TranscriptomicsExpression data from primary Glioblastoma in adults
Gene expression profiling revealed over-representation of a distinct (proneural-like) expression signature in long-term survivors that was linked to IDH1/2 mutation. However, among the IDH1/2-wildtype patients, tumors from long-term survivors did not show distinct gene expression profiles and includ...
ORGANISM(S): Homo sapiens 
2014-03-27 | E-GEOD-53733 | biostudies-arrayexpress
UnknownCerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated <i>ROS1/NTRK</i>-Fusion Positive Pediatric High-Grade Glioma.
Targeting oncogenic fusion-genes in pediatric high-grade gliomas (pHGG) with entrectinib has emerged as a highly promising therapeutic approach. Despite ongoing clinical studies, to date, no reports on the treatment of cerebrospinal fluid (CSF) disseminated fusion-positive pHGG exist. Moreover, clin...
S-EPMC7766483 | biostudies-literature
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