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ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
UnknownComplex alpha-pyrones synthesized by a gold-catalyzed coupling reaction.
Not available
S-EPMC2790064 | biostudies-literature
TranscriptomicsDifferential gene expression in mutants of Arabidopsis FAX1 compared to wild type
DNA microarray analysis (Affymetrix ATH1 GeneChip) on mutant lines of the gene At-FAX1 (At3g57280) in Arabidopsis thaliana was performed as described in Li et al. (2015). In total we analyzed the following comparisons: (A) flowers: fax1 knockout (n = 5) versus wild type (n = 5); (B) flowers: FAX1 ov...
ORGANISM(S): Arabidopsis thaliana 
2015-02-04 | E-MTAB-3090 | biostudies-arrayexpress
TranscriptomicsFlagellin_Illumina_Microarray
the aim of the study was to assess the role of flagellin in the interaction bwetween Salmonella Typhi and host cells. A macrophage-like cell line (THP1) and an epithelial cell line (Hep2) were infected with S. Typhi expressing one of three flagellin variants: Hd, Hj or Hz66. A non-flagellated muta...
ORGANISM(S): Homo Sapiens 
2014-07-01 | E-MTAB-2395 | biostudies-arrayexpress
TranscriptomicsReplication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast
Histone modifications affect DNA-templated processes ranging from transcription to genomic replication. In this study, we examine the cell cycle dynamics of the trimethylated form of histone H3 lysine 4 (H3K4me3), a mark of active chromatin that is viewed as â??long-livedâ?? [1], and that is involve...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14565 | biostudies-arrayexpress
Transcriptomicsgene expression in human subcutaneous adipose tissue after CLA intervention
Iisomer-specific effects of conjugated linoleic (CLA) supplementation on gene expression with particular consideration of the PPAR 2 Pro12Ala SNP in human adipose tissue. Effect of CLA supplementation on genome wide gene expression in adipose tissue biopsies from 5 PPARg2 Ala12Ala and 5 PPARg2 Pro12...
ORGANISM(S): Homo sapiens 
2009-09-01 | E-GEOD-16615 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of TNF-alpha stimulated THP-1 cells
The series was designed to obtain gene expression patterns of TNF-alpha stimulated THP-1 cells. Keywords: TNF-alpha stimulation This series represents a group of 15 samples in two groups: 7 samples derived from not stimulated THP-1 cells, 8 from THP-1 cells stimulated with TNF-alpha in a final conce...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10106 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human cells after lipopolysaccharide stimulation, to identify binding of NF-KappaB family members
The NF-KappaB family of transcription factors plays a critical role in numerous cellular processes, particularly the immune response. Our understanding of how the different NF-kappaB subunits act coordinately to regulate gene expression is based on a limited set of genes. We used genome-scale locati...
ORGANISM(S): Homo sapiens 
2006-05-09 | E-WMIT-6 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of TNF-alpha stimulated CaCo-2 cells
The series was designed to obtain gene expression patterns of TNF-alpha stimulated CaCo-2 cells. Keywords: TNF-alpha stimulation This series represents a group of 18 samples in 2 groups: 10 samples derived from not stimulated CaCo-2 cells, 8 samples from CaCo-2 cells stimulated with TNF-alpha in fin...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10108 | biostudies-arrayexpress
ProteomicsType 2 diabetes-associated variants disrupt function of SLC16A11, a proton-coupled monocarboxylate transporter, through two distinct mechanisms
Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Carr SA, Schenone M, Ng MCY, Chen BH, MEDIA Consortium, SIGMA T2D Consortium, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES. 2017 Cell. Type 2 Diabetes (T2D) af...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-23 | MSV000081105 | MassIVE
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