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TranscriptomicsMicroarray analysis of surgical liver biopsies from 13 obese (nine with type 2 diabetes) and five control subjects
Hepatic lipid accumulation is an important complication of obesity linked to risk for type 2 diabetes. To identify novel transcriptional changes in human liver which could contribute to hepatic lipid accumulation and associated insulin resistance and type 2 diabetes (DM2), we evaluated gene expressi...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-15653 | biostudies-arrayexpress
TranscriptomicsHuman telomerase RNA processing and quality control
RNA sequencing of HeLa cells treated with siRNA against the RNA exosome components hRRP40, hRRP6, hDIS3, and hRRP6/hDIS3 or the splicing inhibitors Isoginkgetin and spliceostatin A, respectively. Stranded, ribo-depleted RNA seq profiles of HeLa cells treated with exosome targeting siRNAs or splicing...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-72055 | biostudies-arrayexpress
TranscriptomicsHuman telomerase RNA processing and quality control
Primary telomerase RNA transcripts are processed into shorter mature forms that assemble into a complex with the catalytic subunit and provide the template for telomerase activity. In diverse fungi telomerase RNA 3’ end processing involves a single cleavage reaction by the spliceosome akin to the...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-73776 | biostudies-arrayexpress
TranscriptomicsIncreased SRF Transcriptional Activity is a Novel Signature of Insulin Resistance in Humans and Mice
Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) and is even present in offspring of diabetic parents. However, molecular mediators of insulin resistance remain unclear. We find that the top-ranking gene set in expression analysis of muscle from humans w...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-25462 | biostudies-arrayexpress
UnknownMachine learning driven prediction of cerebrospinal fluid rhinorrhoea following endonasal skull base surgery: A multicentre prospective observational study.
Not available
S-EPMC10076706 | biostudies-literature
UnknownSociodemographic, Clinical, and Psychosocial Predictors of Short- and Long-term Study Retention in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).
Not available
S-EPMC12451849 | biostudies-literature
UnknownA second update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC10482689 | biostudies-literature
UnknownAnalysis of Long-term Follow-up of a Randomized Clinical Trial With Departures From Assigned Treatments: Estimation of Metformin Effects on Diabetes and Its Complications in the Diabetes Prevention Program Outcomes Study.
Not available
S-EPMC12451852 | biostudies-literature
UnknownLongitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks.
Not available
S-EPMC12451836 | biostudies-literature
UnknownGenome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.
Not available
S-EPMC10790310 | biostudies-literature
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