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TranscriptomicsThe G Protein-coupled Receptor P2Y14 Influences Insulin Release and Smooth Muscle Function in Mice
UDP-sugars were identified as extracellular signaling molecules, assigning a new function to these compounds in addition to their well defined role in intracellular substrate metabolism and storage. Previously regarded as an orphan receptor, the G protein-coupled receptor (GPCR) P2Y14 (GPR105) was f...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59285 | biostudies-arrayexpress
TranscriptomicsInvestigating GPR34 expression regulation using whole transcriptome sequencing of spleens and dendritic cells from wildtype and GPR34 knockout mice
Naive spleens as well as naive and LPS-treated dendritic cells from wildtype and GPR34-/- mice were sequenced to integrate expression profiles with protein interaction networks and find functional modules that are affected by GPR34 Expression profiles of dendritic cells and whole spleens were genera...
ORGANISM(S): Mus musculus 
2016-03-02 | E-GEOD-68155 | biostudies-arrayexpress
TranscriptomicsCLN3 patients with differing progression of the disease
Mutations in the CLN3 gene lead to juvenile neuronal ceroid lipofuscinosis, a pediatric neurodegenerative disorder characterized by visual loss, epilepsy and psychomotor deterioration. Although most CLN3 patients carry the same 1 kb deletion in the CLN3 gene, their disease phenotype can be variable....
ORGANISM(S): Homo sapiens 
2011-06-08 | E-GEOD-22225 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Expression Profiling of cultured B-CLL cells
Increased survival of primary B-CLL cells cultured in high cell density: Evidence for activation of pathways also induced by stromal cells. Expression profiles of B-CLL cells before and after three different survival-inducing culture conditions: (1) stromal cell coculture [HCo], (2) stromal cell con...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-18192 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression programm during cardiac development in contrasting rat strains SHRSP and F344
Reactivation of fetal gene expression patterns has been demonstrated to play a crucial role in common cardiac diseases in adult life including left ventricular (LV) hypertrophy (LVH). Thus, increased wall stress and neurohumoral activation are discussed to induce the return to expression of fetal ge...
ORGANISM(S): Rattus norvegicus 
2014-07-01 | E-GEOD-53512 | biostudies-arrayexpress
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