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TranscriptomicsOverexpression of Gfi1b in a pro-B Abelson murine leukemia virus transformed cell line
We have conducted a screen for factors that downregulate expression of the genes encoding the V(D)J recombinase (RAG1 and RAG2) during B cell development. We have identified the transcription factor Gfi1B as being one of the proteins capable of decreasing RAG transcription when overexpressed in Ab...
ORGANISM(S): Mus musculus 
2011-12-13 | E-GEOD-33709 | biostudies-arrayexpress
TranscriptomicsGFI deficiency in plasmacytoid dendritic cells
Growth factor independence genes (Gfi1 and Gfi1b) repress recombination activating genes (Rag) transcription in developing B lymphocytes. Because all blood lineages originate from hematopoietic stem cells (HSCs) and different lineage progenitors have been shown to share transcription factor networks...
ORGANISM(S): Mus musculus 
2013-04-07 | E-GEOD-45837 | biostudies-arrayexpress
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