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Nuclear depletion of the essential transcription termination factor Nrd1 in Saccharomyces cerevisiae was studied using a combination of RNA-Seq, ChIP-Seq of Pol II and PAR-CLIP of Nrd1. The drug rapamycin induces the formation of a ternary complex between a protein of interest, the drug and the smal...
ORGANISM(S): Saccharomyces cerevisiae 
Bacterial extracellular vesicles (EVs), lipid bilayered particles ranging from 20 to 400 nm, are secreted by bacteria and carry cargo including proteins, lipids, and nucleic acids. EVs composition varies between Gram-positive and Gram-negative bacteria, and they contain pathogen recognition receptor...
ORGANISM(S): Lactobacillus plantarum Bacteria 
2026-09-07 | PXD060959 | Pride
To understand differences between resting and activated memory CD8+ T cells, we compared the global gene expression of ex vivo isolated naive and spleen and BM memory cells to in vitro activated spleen and BM memory cells. Single cell suspension from the spleen and bones of aged C57BL/6 mice were pr...
ORGANISM(S): Mus musculus 
This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines including information on origin, mutation status of genes implicated in bladder cancer (FGFR3, PIK3CA, TP53, and RAS), copy number alterations assessed using high density SNP arrays, uniparental diso...
ORGANISM(S): Homo sapiens 
This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines including information on origin, mutation status of genes implicated in bladder cancer (FGFR3, PIK3CA, TP53, and RAS), copy number alterations assessed using high density SNP arrays, uniparental diso...
ORGANISM(S): Homo sapiens 
To obtain rates of mRNA synthesis and decay in yeast, we established dynamic transcriptome analysis (DTA). DTA combines non-perturbing metabolic RNA labeling with dynamic kinetic modeling. DTA was used to monitor the cellular response to osmotic stress in comparison to the wild type. Genomic occupa...
ORGANISM(S): Saccharomyces cerevisiae 
Tumor associated macrophages and T cells were characterized in a cohort of 73 ccRCC and 5 healthy donors using mass cytometry. Macrophage and T cell subsets of interest were identified and sorted directly from samples known to contain a high frequency of these subsets. CD8+ PD-1- T cells (n=6), exha...
ORGANISM(S): Homo sapiens 
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