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TranscriptomicsTranscription profiling of SBH/y rats vs SBN/y rats under basal conditions and after salt loading
Gene expression was studied in whole kidneys in a 2 x 2 design. SBH/y were contrasted with SBN/y under basal conditions and after salt loading. Thus, four groups were studied altogether. Five rats were used in each group. Altogether, 20 animals were used, and each animal was studied separately. G...
ORGANISM(S): Rattus norvegicus 
2004-09-10 | E-MEXP-157 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of gonads from E14.5 megalin+/+ and megalin-/- embryos
Presently, genes regulated by steroid hormones during induced regression of the CSL (cranial suspensory ligament) are unknown. To identify such genes and to evaluate their expression levels in megalin-deficient mice, we performed global gene expression profiling on gonads from E14.5 megalin+/+ and m...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-352 | biostudies-arrayexpress
TranscriptomicsThe UBC-40 Urothelial Bladder Cancer Cell Line Index [copy number variation]
This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines including information on origin, mutation status of genes implicated in bladder cancer (FGFR3, PIK3CA, TP53, and RAS), copy number alterations assessed using high density SNP arrays, uniparental diso...
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-64572 | biostudies-arrayexpress
TranscriptomicsThe UBC-40 Urothelial Bladder Cancer Cell Line Index [gene expression]
This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines including information on origin, mutation status of genes implicated in bladder cancer (FGFR3, PIK3CA, TP53, and RAS), copy number alterations assessed using high density SNP arrays, uniparental diso...
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-64279 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats with rare arterial and renal phenotypes
The Brown Norway (BN) strain of rat is an inbred normotensive strain. BN rats of both sexes present some interesting pathophysiological phenotypes involving arteries and the kidneys. These include internal elastic lamina (IEL) ruptures in the abdominal aorta and iliac arteries, a deficit in aortic e...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6215 | biostudies-arrayexpress
TranscriptomicsA combined RNAi and localization approach for dissecting long noncoding RNAs reveals a function of Panct1 in ES cells
Long non-coding RNAs (lncRNAs) regulate diverse biological pathways. Unlike protein coding genes, where methods to comprehensibly study their functional roles in cellular systems are available, techniques to systematically investigate lncRNAs have largely remained unexplored. Here, we report a techn...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-29798 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skeletal and cardiac muscles in dysferlin-deficient SJL/J mice and wild type mice to understand the protective mechanisms against dysferlin deficiency in cardiac muscles.
Dysferlin is expressed in skeletal and cardiac muscle. However, dysferlin deficiency, namely limb girdle muscular dystrophy 2B (LGMD2B) and Myoshi myopathy, results in skeletal muscle weakness and spares the heart. This dichotomy could be caused by differential regulation of protective mechanisms. T...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2507 | biostudies-arrayexpress
TranscriptomicsAnalysis of embryonic day E14.5 and E16.5 mouse ureters from Tshz3LacZ/LacZ mutants and wild types
In the urinary tract, smooth muscle (SM) is present in the renal pelvis, the ureter, the bladder and the urethra and plays a crucial role in the functional and structural integrity of these organs. In Tshz3 mutant ureters the myogenic program is not activated in the proximal region due to the absenc...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-43940 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peritoneal fat of SHR/01a (spontaneously hypertensive rat), BN-Lx (Brown Norway congenic carrying polydactyly-luxate syndrome)and recombinant inbred (HXB/BXH) 6-week old rat strains
Gene expression profiling of peritoneal fat of SHR/01a (spontaneously hypertensive rat), BN-Lx (Brown Norway congenic carrying polydactyly-luxate syndrome)and recombinant inbred (HXB/BXH) 6-week old rat strains.
ORGANISM(S): Rattus norvegicus 
2010-11-18 | E-AFMX-7 | biostudies-arrayexpress
TranscriptomicsComparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program
Identifying the genetic program that induces limb regeneration in salamanders is an important resource for regenerative medicine, which currently lacks tools to promote regeneration of functional body structures. The genetic network underlying limb regeneration has been elusive due to the complexit...
ORGANISM(S): Ambystoma mexicanum 
2013-01-01 | E-GEOD-36451 | biostudies-arrayexpress
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