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TranscriptomicsChromatin immunoprecipitation of three PcG proteins and of histone H3 trimethylated at Lys 27 in Drosophila
We determined the distribution of three PcG proteins: PC, PSC and E(Z), and of histone H3 trimethylated at Lys 27 by chromatin immunoprecipitation (ChIP) coupled with analysis of immunoprecipitated DNA with a high density genomic tiling microarray (Affymetrix).
ORGANISM(S): Drosophila melanogaster 
2006-12-30 | E-MEXP-535 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse strains responsive/unresponsive to asbestos backcrossed to either C57B or 129
Asbestos disease model: Occupational lung disease comprises a wide variety of disorders caused by the inhalation or ingestion of dust particles or noxious chemical. These disorders include pneumoconiosis, asbestos-related pleural and others. Although asbestos is carcinogenic to humans, the mech...
ORGANISM(S): Mus musculus 
2007-02-14 | E-TIGR-10 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 36 individuals with autism spectrum disorder
To assess the clinical impact of splice-altering noncoding mutations in autism spectrum disorder (ASD), we used a deep learning framework (SpliceAI) to predict the splice-altering potential of de novo mutations in 3,953 individuals with ASD from the Simons Simplex Collection. To validate these predi...
ORGANISM(S): Homo sapiens 
2018-11-25 | E-MTAB-7351 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of LPS-stimulated RAW264.7 macrophages overexpressing Tbc1d23 novel innate immune gene
We previously identified Tbc1d23 as a candidate novel regulator of innate immunity using comparative genomics RNAi screens in C. elegans and mouse macrophages. Using mice with an engineered knockout mutation in Tbc1d23 and macrophages engineered to overexpress Tbc1d23, we now show that Tbc1d23 is a ...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-30840 | biostudies-arrayexpress
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
UnknownIndirect Evidence for Genetic Differentiation in Vulnerability to Embolism in Pinus halepensis.
Not available
S-EPMC4889591 | biostudies-literature
UnknownAssociation of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study.
Not available
S-EPMC11485411 | biostudies-literature
UnknownDe novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Not available
S-EPMC7007577 | biostudies-literature
UnknownClinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment.
Not available
S-EPMC11503049 | biostudies-literature
GenomicsHigh salt reduces the activation of IL-4+IL-13 stimulated macrophages
High salt (NaCl) intake is a major risk factor for cardiovascular disease; high NaCl has also been shown to be a powerful modulator of pro-inflammatory immune cell polarization. To investigate the effect of high NaCl on the polarization of M(IL-4+IL-13) macrophages we performed gene expression analy...
ORGANISM(S): Mus musculus 
2015-02-07 | E-MTAB-3140 | biostudies-arrayexpress
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