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TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone marks in E(z) temperature sensitive cells [ChIP-seq]
PcG protein complex PRC2 is a methyltransferase specific for histone H3 lysine27, and H3K27me3 is essential for stable transcription silencing. Less well known but quantitatively much more important is the genome-wide role of PRC2 that dimethylates ~70% of total H3K27. Here we show that H3K27me2 occ...
ORGANISM(S): Drosophila melanogaster 
2015-05-14 | E-GEOD-64219 | biostudies-arrayexpress
GenomicsGenome-wide analysis of epigenetic marks in E(z) temperature sensitive cells [ChIP-seq]
PcG protein complex PRC2 is a methyltransferase specific for histone H3 lysine27, and H3K27me3 is essential for stable transcription silencing. Less well known but quantitatively much more important is the genome-wide role of PRC2 that dimethylates ~70% of total H3K27. Here we show that H3K27me2 occ...
ORGANISM(S): Drosophila melanogaster 
2015-05-14 | E-GEOD-61308 | biostudies-arrayexpress
UnknownTelehealth personalized cancer risk communication to motivate colonoscopy in relatives of patients with colorectal cancer: the family CARE Randomized controlled trial.
Not available
S-EPMC3927734 | biostudies-literature
ProteomicsCombined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor
AKT activation is a hallmark of IM resistance in GIST. The presence of an additional therapeutic agent could potentially suppress the growth and survival of a clone of cancer cells, which have developed resistance to IM. Simultaneous targeting of AKT in addition to inhibiting KIT with IM has potenti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-20 | MSV000086739 | MassIVE
TranscriptomicsDifferential gene expression in the Lacrimal gland during development and onset of xerostomia in Sjogren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse.
Recently, we reported the development of the C57BL/6.NOD-Aec1Aec2 mouse that carries two genetic intervals derived from the NOD mouse capable of conferring Sjogren's syndrome (SjS)-like disease in SjS-non-susceptible C57BL/6 mice. In an attempt to define the molecular bases underlying onset of stoma...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-48139 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of three PcG proteins and of histone H3 trimethylated at Lys 27 in Drosophila
We determined the distribution of three PcG proteins: PC, PSC and E(Z), and of histone H3 trimethylated at Lys 27 by chromatin immunoprecipitation (ChIP) coupled with analysis of immunoprecipitated DNA with a high density genomic tiling microarray (Affymetrix).
ORGANISM(S): Drosophila melanogaster 
2006-12-30 | E-MEXP-535 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of MED patient-derived (MATN3 V194D) and unaffected iPSC-chondrogenesis
PBMCs from MED patients carrying the MATN3 V194D mutation and unaffected controls were reprogrammed into hiPSCs. Samples were differentiated into Day 21 cartilage pellets via an iMSC intermediate.
ORGANISM(S): Homo sapiens 
2026-02-12 | E-MTAB-16600 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of MED patient-derived (MATN3 T195K) and unaffected iPSC-chondrogenesis
PBMCs from MED patients carrying the MATN3 T195K mutation and unaffected controls were reprogrammed into hiPSCs using Sendai virus. Data includes three differentiation stages: pluripotent hiPSCs, iMSCs, and Day 21 cartilage pellets. Sequencing was performed at the University Genomics Core Facility.
ORGANISM(S): Homo sapiens 
2026-02-12 | E-MTAB-16598 | biostudies-arrayexpress
GenomicsPediatric Investigation of Genetic Factors Linked with Renal Progression (PediGFR): Chronic Kidney Disease in Children Cohort (CKiD)

The Pediatric Investigation for Genetic Factors Associated with Renal Progression (PediGFR) (RO1-DK082394) is an international collaborative study among three large prospective cohort studies of children with chronic kidney disease. The participating parent cohort studies are the "Chronic Kidney ...

phs000650.v1.p1 | EGA
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