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TranscriptomicsImpact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia
We found previously that the effect of decitabine (DAC) on hematopoietic stem cell viability differed between Mll5 wildtype and null cells. We therefore investigated the role of MLL5 expression levels on outcome of AML patients who were treated with decitabine. High MLL5 expressing AML patients have...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-52199 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of MN1 and MN1VP16 in murine bone marrow cells
Myeloid differentiation is blocked in acute myeloid leukemia (AML), but the molecular mechanisms are not well characterized. MN1 is overexpressed in some AML patients and confers resistance to all-trans retinoic acid (ATRA)-induced differentiation. To understand the role of MN1 as a transcriptional ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-48819 | biostudies-arrayexpress
UnknownNeuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.
Not available
S-EPMC11086946 | biostudies-literature
TranscriptomicsGene expression changes induced by overexpression of IDH1mut in the sorted mouse bone marrow cells
Mutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer, lymphoma, melanoma, and in acute myeloid leukemia. Mutated IDH1/2 produces the metabolite 2-hydroxyglutarate (2HG), which interferes with epigenetic regulation of gene...
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-45019 | biostudies-arrayexpress
UnknownArthroplasty-CervicalP001 - Double Crush Syndrome of the Vertebral Artery Loop and Foraminal Stenosis Causing Monoparesis
Not available
S-EPMC5724662 | biostudies-literature
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