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TranscriptomicsVariability in functional p53 reactivation by Prima-1Met/APR-246 in Ewing sarcoma
Though p53 mutations are rare in Ewing sarcoma, there is a strong indication that p53-mutant tumors form a particularly bad prognosis group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumor cells containing mutant-p53 in this subset of ES patients....
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-49967 | biostudies-arrayexpress
UnknowneDNA as a tool for non-invasive monitoring of the fauna of a turbid, well-mixed system, the Elbe estuary in Germany.
Not available
S-EPMC8051793 | biostudies-literature
TranscriptomicsNotch is active in Langerhans Cell Histiocytosis and confers pathognomonic features on dendritic cells.
Langerhans cell histiocytosis (LCH) is a disease characterized by the accumulation of eponymous CD1a+ Langerin+ Langerhans-cell (LC)-like dendritic cells (DC) of largely unknown origin. Here we have performed comparative transcriptome analysis of highly purified CD207+/CD1a+ Langerhans cell histiocy...
ORGANISM(S): Homo sapiens 
2012-10-24 | E-GEOD-35340 | biostudies-arrayexpress
UnknownSuppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma.
Not available
S-EPMC4114138 | biostudies-literature
TranscriptomicsRe-activation of EWS-FLI1 suppressed FOXO1 expression as a novel therapeutic strategy for Ewing´s sarcoma
Transient transfection of a Ewing's Sarcoma cell line expressing type I EWS-FLI1 fusion and doxycycline-inducible short hairpin RNA against EWS-FLI1 (A673sh) In total, 7 samples were analysed: empty vector control and two nuclear directed AKT- and CDK2- phosphorylation resistant FOXO1 versions as we...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-37409 | biostudies-arrayexpress
UnknownVemurafenib acts as a molecular on-off switch governing systemic inflammation in Langerhans cell histiocytosis.
Not available
S-EPMC8945316 | biostudies-literature
UnknownHigh Substrate Uptake Rates Empower Vibrio natriegens as Production Host for Industrial Biotechnology.
Not available
S-EPMC5666143 | biostudies-literature
UnknownHigh Connectivity at Abyssal Depths: Genomic and Proteomic Insights Into Population Structure of the Pan‐Atlantic Deep‐Sea Bivalve Ledella ultima (E. A. Smith, 1885)
Not available
S-EPMC12332424 | biostudies-literature
UnknownEWS-FLI1 employs an E2F switch to drive target gene expression.
Not available
S-EPMC4357724 | biostudies-literature
UnknownThe role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma.
Not available
S-EPMC5355239 | biostudies-literature
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