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TranscriptomicsVariability in functional p53 reactivation by Prima-1Met/APR-246 in Ewing sarcoma
Though p53 mutations are rare in Ewing sarcoma, there is a strong indication that p53-mutant tumors form a particularly bad prognosis group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumor cells containing mutant-p53 in this subset of ES patients....
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-49967 | biostudies-arrayexpress
TranscriptomicsRe-activation of EWS-FLI1 suppressed FOXO1 expression as a novel therapeutic strategy for Ewing´s sarcoma
Transient transfection of a Ewing's Sarcoma cell line expressing type I EWS-FLI1 fusion and doxycycline-inducible short hairpin RNA against EWS-FLI1 (A673sh) In total, 7 samples were analysed: empty vector control and two nuclear directed AKT- and CDK2- phosphorylation resistant FOXO1 versions as we...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-37409 | biostudies-arrayexpress
TranscriptomicsA functional liaison between E2F and the aberrant ETS oncogene EWS/FLI1 in Ewing's sarcoma
Translocations of ETS transcription factors are driver mutations in diverse cancers. We investigated the genomic network of the ETS fusion EWS/FLI1 in Ewing's sarcoma (ESFT) as a model of ETS-driven tumorigenesis. ChIP-Seq and transcriptional analysis identified E2F3 as a principle co-factor of EWSF...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-27524 | biostudies-arrayexpress
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