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TranscriptomicsTranscription profiling time series of fission yeast after selective inhibition of Mcs6 and Cdk9
Selective inhibition of S. pombe Mcs6, Cdk9, or both via bulky nucleotide analogue.
ORGANISM(S): Schizosaccharomyces pombe 
2009-03-30 | E-MEXP-1746 | biostudies-arrayexpress
TranscriptomicsA positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B mono-ubiquitylation to regulate transcript elongation in fission yeast
Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification within transcribed regions, but it remains uncertain how these modifications influence, or are influenced by, properties of the elongation complex. Here we establish an intimate link betw...
ORGANISM(S): Schizosaccharomyces pombe 
2012-12-01 | E-GEOD-31070 | biostudies-arrayexpress
TranscriptomicsIndividual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast
The primary structure and phosphorylation pattern of the tandem YSPTSPS repeats of the RNA polymerase II CTD comprise an informational code that coordinates transcription, chromatin modification, and RNA processing. To gauge the contributions of individual CTD coding M-bM-^@M-^\lettersM-bM-^@M-^] to...
ORGANISM(S): Schizosaccharomyces pombe 
2014-03-13 | E-GEOD-52370 | biostudies-arrayexpress
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