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TranscriptomicsLong Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining is critical for neural development, and brain cells frequently contain somatic genomic variations that might involve DSB intermediates. We now use an unbiased, high-throughput approach to identify genomic regions harboring recur...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-74356 | biostudies-arrayexpress
GenomicsLong-range joining of intra-chromosomal DNA double-strand breaks
Antibody class switch recombination (CSR) in B lymphocytes joins two DNA double-strand breaks (DSBs) lying 100 to 200 kilobases (kb) apart within switch (S) regions in the immunoglobulin heavy chain locus (IgH). CSR-activated B lymphocytes generate multiple S-region DSBs in the donor Sm and in a do...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-53755 | biostudies-arrayexpress
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