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GenomicsTranscriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4 (ChIP-seq)
Temporal analysis of Irf4 and PU.1 genome binding during B cell activation and differentiation in vitro using antigen (NP-Ficoll) CD40L and IL-2/4/5 cytokines (see Molecular Systems Biology 7:495 for details of cellular system). The results provide insight in the target genes and binding specificity...
ORGANISM(S): Mus musculus 
2013-05-04 | E-GEOD-46607 | biostudies-arrayexpress
TranscriptomicsIRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Affymetrix).
While most blood lineages are assumed to mature through a single cellular and developmental route downstream of hematopoietic stem cells (HSCs), dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downst...
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34892 | biostudies-arrayexpress
TranscriptomicsTranscriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4 (expression)
Temporal analysis of B cell activation in vitro using CD40L and IL-2/4/5 cytokines in wild type Irf4+/+ B cells or in mutant Irf4-/- B cells harboring a tet-inducible allele of Irf4. IRF4 expression was restored, or not, in the Irf4-/- background by culturing in the presence of low or high concentra...
ORGANISM(S): Mus musculus 
2013-05-04 | E-GEOD-46606 | biostudies-arrayexpress
TranscriptomicsIRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Illumina).
While most blood lineages are assumed to mature through a single cellular and developmental route downstream of hematopoietic stem cells (HSCs), dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downst...
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34915 | biostudies-arrayexpress
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